ExpressGraft™ skin tissue:

Stratatech’s second generation therapeutic product line is called ExpressGraft™ skin tissue. This is a pipeline of advanced wound-healing, human skin substitutes engineered to express and secrete factors targeted to fight bacterial infection, promote angiogenesis, and promote wound healing in chronic ulcers. Research conducted by Dr. Allen-Hoffmann and her team has successfully demonstrated that the NIKS™ cells can be genetically enhanced with non-viral vectors to over-express a variety of natural, human wound-healing factors. Importantly, these enhanced NIKS™ cells produce normal skin and exhibit long-term expression of the wound-healing genes. Currently, ExpressGraft™ products are being genetically engineered to individually “super express” three different wound healing factors: for enhanced blood vessel formation, enhanced antimicrobial action, and increased rate of healing with reduced scarring. The Company believes these product features will translate into important benefits, which include faster, more complete wound healing from “super expression” of natural wound healing substances.